Tag Archives: HEU infants

HIV-Exposure and Infant Mortality in Botswana

By Martha Henry

The AIDS epidemic has had a devastating impact on child survival in sub-Saharan Africa. In Botswana, under-five mortality almost doubled from 1990 to 2000. Since then, remarkable progress has been made to prevent pregnant HIV-positive mothers from passing the virus to their infants, either in utero or through breastfeeding. Yet in a study published this July in BMC Pediatrics, Harvard AIDS Initiative (HAI) researchers found that HIV-exposed or infected children in Botswana account for more than half of deaths in children younger than two. Continue reading

The Microbiome’s Role in an Infant’s Developing Immune System


The role bacteria play in human health—what’s termed our microbiome—has been much in the news lately. Each person is host to a unique assortment and concentration of over 100 trillion bacterial cells, most of which are beneficial. For example, the bacteria in our gut help us digest food and produce some of the vitamins we require. They also have a strong influence on everything from mental health to the immune system.

Dr. Kate Powis
Dr. Kate Powis (photo by Kent Dayton)

Dr. Kate Powis, a clinician and researcher at the Harvard T.H. Chan School of Public Health AIDS Initiative (HAI), is studying the gut microbiome of HIV exposed but uninfected (HEU) infants. These HEU babies are born to HIV-positive mothers, and even though the babies don’t have the virus, they are two to three times more likely to die in the first two years of life than babies born to HIV-negative mothers. Over 1.5 million HEU children will be born this year.

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