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Vaccine Think Tank

Symposium Series on
Vaccine Solutions for Developing Countries


A Report of HAI

April 6-9, 1998
Boston, Massachusetts, USA

Sponsor
HAI

Cosponsors
Albert B. Sabin Vaccine Institute at Georgetown University
Fogarty International Center
International AIDS Vaccine Initiative
Joint United Nations Programme on HIV/AIDS
United States Military HIV Research Programme
Until There’s a Cure Foundation

HIV Vaccines for Developing Countries: Immune Correlates of Protection was sponsored by HAI, with generous support from Albert B. Sabin Vaccine Institute at Georgetown University; Fogarty International Center; International AIDS Vaccine Initiative; Joint United Nations Programme on HIV/AIDS; United States Military HIV Research Programme; and Until There’s a Cure Foundation.

This report was produced by HAI.

TABLE OF CONTENTS

Introduction
What national and international vaccine trials are currently underway around the world? What trials are planned for the future? What are the unique capabilities of each site?
Country Report: Thailand
What is known about immune correlates in other human infections?
Country Report: Sénégal
What do cohort observational studies tell us about immune correlates?
Country Report: Tanzania
How can vaccine trials be designed and analyzed to help us learn more about immune correlates of protection?
Country Report: Brazil
What is the state-of-the-art in immune correlates of protection against HIV infection or disease progression?
What conclusions about immune correlates of protection can be learned from HIV vaccine trials to date? What can be concluded from Phase I/II trials? What are the limitations of current plans or trials?
Country Report: South Africa
How is mucosal immunity measured, and what role does it play in the immune response to pathogens?
What can be learned from animal viral diseases and attempts at creating vaccines for such viral diseases? What can be learned from animal models to identify immune correlates of protection?
Country Report: Botswana
Conclusion
Appendix: Symposium Participants

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